Raw Materials Knowledge Base¶

Quality parameters and selection guides for peptide synthesis raw materials.

Categories¶

Amino Acids¶

• Fmoc Amino Acids — Standard protected amino acids for Fmoc SPPS
• Boc Amino Acids — Protected amino acids for Boc SPPS

Resins¶

• Wang Resin — Standard for C-terminal carboxylic acid
• Rink Amide Resin — For C-terminal amide peptides

Activators¶

• HBTU — Standard coupling reagent
• HATU — High-efficiency coupling reagent
• DIC — Carbodiimide activator
• Oxyma — Safer additive alternative to HOBt

Solvents¶

• DMF — Primary reaction solvent
• DCM — Resin swelling and wash solvent
• Acetonitrile — HPLC mobile phase
• TFA — Cleavage and deprotection reagent
• Supplier Qualification — Evaluating and qualifying raw material suppliers