DCM — Dichloromethane
Resin Swelling and Wash Solvent
Definition
DCM (dichloromethane) is used in SPPS primarily for resin swelling and as a wash solvent.
Specifications
| Parameter | Typical Value |
| Purity | ≥99.8% |
| Water content | ≤0.02% |
| Grade | Synthesis grade |
Role in SPPS
| Function | Detail |
| Resin swelling | Best swelling for polystyrene resins (6–8 mL/g) |
| Pre-swelling | Before first coupling in DMF |
| Wash | After DMF washes, before DMF again |
| Cleavage cocktail component | Diluent for TFA |
Handling
| Hazard | Precaution |
| Toxic (suspected carcinogen) | Fume hood |
| Irritant | Gloves, goggles |
| Volatile | Keep container sealed |
Key Takeaways
- Resin Swelling and Wash Solvent — Review the section above for key parameters, methods, and quality criteria.
- Definition — Review the section above for key parameters, methods, and quality criteria.
- Specifications — Review the section above for key parameters, methods, and quality criteria.
- Role in SPPS — Review the section above for key parameters, methods, and quality criteria.
🔗 Related: DMF | Resin Loading | SPPS Process