DIC — N,N'-Diisopropylcarbodiimide¶
Carbodiimide Coupling Reagent¶
Definition¶
DIC (N,N'-diisopropylcarbodiimide) is a carbodiimide coupling reagent used with an additive (HOBt, HOAt, or Oxyma) for amide bond formation.
Specifications¶
| Parameter | Typical Value |
|---|---|
| Purity | ≥99% |
| Form | Liquid |
| Storage | 2–8 °C |
| CAS number | 693-13-0 |
Advantages¶
- Low epimerization (with Oxyma)
- No base required
- Economical at scale
- Good for green chemistry (byproduct is water-soluble)
Typical Conditions¶
| Parameter | Value |
|---|---|
| Equivalents | 3 eq DIC + 3 eq additive |
| Solvent | DMF or DCM |
| Temperature | RT or 50 °C |
| Time | 30–60 minutes |
Safety Note¶
DIC is a sensitizer and irritant. Handle in fume hood with appropriate PPE.
- Carbodiimide Coupling Reagent — Review the section above for key parameters, methods, and quality criteria.
- Typical Conditions — Review the section above for key parameters, methods, and quality criteria.
Key Takeaways¶
- Carbodiimide Coupling Reagent — Review the section above for key parameters, methods, and quality criteria.
- Definition — Review the section above for key parameters, methods, and quality criteria.
- Specifications — Review the section above for key parameters, methods, and quality criteria.
- Advantages — Review the section above for key parameters, methods, and quality criteria.
🔗 Related: Oxyma | HBTU | Coupling Reaction